Overview

The course will give you an advanced understanding of protein structure-function in the context of human disease. Major themes relate the various levels of protein structure to their wide ranging functions, introduce modern techniques used in the analysis of structure and function, and explore the rapidly developing area of protein-related … For more content click the Read More button below.

Offerings

S2-01-CLAYTON-ON-CAMPUS

Rules

Enrolment Rule

Contacts

Chief Examiner(s)

Prof Mibel Aguilar

Unit Coordinator(s)

Dr Jackie Wilce

Learning outcomes

On successful completion of this unit, you should be able to:
1.

Describe the relationship between protein sequence, structure and function and relate this to specific examples in human health and disease;

2.

Explain how proteins fold to their correct three dimensional shape and how this process may go wrong and cause disease;

3.

Illustrate how NMR and X-ray crystallography are used to determine the structure of a peptide or protein;

4.

Critically analyse how our understanding of proteins contributes to biotechnology and medicine, in particular comment on the contribution of protein engineering and proteomics to these fields;

5.

Describe the use of fluorescent proteins as tools for characterising the role of proteins in vivo;

6.

Apply experimental techniques and methodologies to determine the structure and function of an unknown protein.

Teaching approach

Active learning

Assessment

1 - Practical theory test
2 - Practicals
3 - In-semester quizzes
4 - Examination (2 hours and 10 minutes)

Scheduled and non-scheduled teaching activities

Lectures
Practical activities
Tutorials

Workload requirements

Workload

Availability in areas of study

Biochemistry, Microbiology