GEN3040 - Genomics and its applications

Overview

Recent technological advances in DNA analysis now allow the rapid and relatively cheap sequencing of entire genomes of individual organisms. These developments have the potential to revolutionize how we identify genes that control both simple and complex traits. Bioinformatic analysis of genomic data will also be highly influential in shaping our view of how organisms adapt to changes in their environment and how over a longer time-scale, traits such as body size and pattern and physiological and behavioral responses can evolve, leading to the rich diversity of life forms seen today. This unit will explore the use of whole-genome techniques to examine gene regulation, identify the genes controlling both simple and complex traits, determine how individuals and populations adapt to selective pressure and piece together the evolutionary changes that have given rise to complex multicellular life. Such information will increasingly be important in the 21st century for sustainable development of human civilization in concert with a healthy planetary environment. You will acquire relevant laboratory and computer-based skills including genetic database analysis and bioinformatics, forward genetic approaches and mapping and identification of genes controlling complex quantitative traits.

Offerings

S1-01-CLAYTON-ON-CAMPUS

S1-01-MALAYSIA-ON-CAMPUS

Rules

Enrolment Rule

Contacts

Chief Examiner(s)

Professor John Bowman

Unit Coordinator(s)

Dr Wee Wei Yee

Dr Callum Vidor

Learning outcomes

On successful completion of this unit, you should be able to:

Describe recent advances in genetic knowledge gained from genomic analysis of species ranging from unicellular to multicellular organisms.

Explain the philosophy of forward and reverse genetics including genome editing techniques.

Determine potential applications for genomic techniques in the areas of medical research, agriculture, biotechnology and environmental management;

Utilise bioinformatic tools to compare DNA and protein sequences, search for genetic variants controlling complex traits, analyse transcriptome data and search for genomic signatures for adaptation;

Illustrate the processes required to map and identify genes controlling complex biological traits and articulate how forward genetics approaches can be used to determine gene function;

Collect, analyse, interpret and present genetic data effectively in the preparation of scientific reports;

Synthesize and critique new discoveries from the scientific literature in genomics.

Teaching approach

Active learning

Laboratory-based classes will complement lectures. You will carry out molecular genetic experimental techniques to gain laboratory skills and practical experience in extracting and analysing DNA (both in the lab and via use of computer and genetic databases) and demonstrating expression ability of regulatory sequences using reporter gene activity. Short tutorials will be held during these classes to further explain detailed technical concepts. You will be required to undertake and complete a set of problem exercises aimed at developing your ability to connect underlying theory with practical activities; undertake laboratory experimental exercises and present your findings in the form of written practical reports with due reference to recent published literature in the field; analyse DNA sequences using computer assisted analysis of genetic databases.

Assessment

1 - Practical releated assignments

2 - In-semester tests

3 - Final assessment - Exam (2 hours and 10 minutes)

Scheduled and non-scheduled teaching activities

Applied sessions

Laboratories

Workload requirements

Workload

Learning resources

Required resources

Other unit costs

Costs are indicative and subject to change.
Lab coat required - $35
Safety footwear at your own cost.

Availability in areas of study

Biochemistry
Biotechnology
Genetics and genomics
Microbiology
Plant sciences
Zoology